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. 2017 Jul 20;8:16110. doi: 10.1038/ncomms16110

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Cladograms of proteins containing the IPR003731 domain. Coloured clades contain members of the NifB (IPR005980, blue), NifX (IPR013480, turquoise) and NafY (IPR031763, purple) InterPro protein families. The proposed IssA clade (red) is based on predicted protein isoelectric point (pI) and occurrence of proteins with a glycine rich region at the C-terminus. P. furiosus IssA and the homologue from Methanothermobacter thermautotrophicus (MTH1175) are shown by red and yellow arrowheads respectively. (b) Modelled structure of the IssA IPR003731 domain based on the NMR structure of MTH1175 (red). The C-terminal region is shown unstructured, as predicted for the apo-form.