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. 2017 Jul 20;8:16032. doi: 10.1038/ncomms16032

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Anatomical reconstruction of reciprocally connected PC and MC in layer 3. PC dendrites (blue) and MC axon (red) covered layer 1 and 3, PC axon (yellow) and MC dendrites (green) mainly occupied layer 3 (inset). Subiculum is to the left and the parasubiculum to the right. Scale bar, 50 μm. (b) Current clamp recordings of a MC (green) and a PC (blue). The MC fired spontaneously, the PC, with a more hyperpolarized membrane potential, was silent. (c) Membrane potential values for 80 MCs (circles, X98-SST, green; SstCre, orange) and 87 PCs (triangles, X98-SST, blue; SstCre, purple). The horizontal bar indicates the mean value, error bars represent s.d. (d) Typical responses of a MC and a PC to negative and positive current step injections of duration 800 ms from −65 mV. (e) Plotting input–output (I–O) gain against threshold current separates PCs (triangles) from MCs (circles; same colour code as in c). For detailed statistics see Supplementary Table 1.