Table 3.
Tensile strength (Ts), crushing strength (Cs), friability (Ft), disintegration time (DT), and DER [(Cs/Ft)/DT] and DERc ratios for paracetamol tablets containing different concentrations of the cassava starch disintegrants.
| Type of cassava starch |
Starch concentration (% w/w) |
T s (N/cm2) | C s (N) | F t (%) | D T (min) | DER | DERc |
|---|---|---|---|---|---|---|---|
| V10 | 5.0 | 75.8 | 63.2 | 0.74 | 12.58 | 6.79 | 0.45 |
| 7.5 | 74.6 | 55.7 | 0.90 | 13.10 | 4.72 | 0.35 | |
| 10.0 | 82.6 | 66.0 | ND | 3.20 | — | — | |
|
| |||||||
| V20 | 5.0 | 91.2 | 77.4 | 0.88 | 14.00 | 6.28 | 0.42 |
| 7.5 | 112.4 | 97.4 | 0.46 | 12.00 | 17.64 | 1.32 | |
| 10.0 | 67.7 | 50.7 | 0.43 | 5.00 | 23.58 | 2.49 | |
|
| |||||||
| V30 | 5.0 | 96.4 | 74.3 | 0.92 | 14.10 | 5.73 | 0.38 |
| 7.5 | 78.0 | 65.8 | 0.89 | 13.06 | 5.66 | 0.42 | |
| 10.0 | 73.1 | 61.3 | 0.71 | 9.10 | 9.49 | 1.00 | |
|
| |||||||
| V40 | 5.0 | 87.2 | 76.1 | 0.28 | 13.40 | 20.28 | 1.35 |
| 7.5 | 94.7 | 94.3 | 0.71 | 10.00 | 13.28 | 0.99 | |
| 10.0 | 69.8 | 55.7 | 0.27 | 4.45 | 46.36 | 4.90 | |
|
| |||||||
| V50 | 5.0 | 117.6 | 98.4 | 0.29 | 14.30 | 23.73 | 1.58 |
| 7.5 | 84.4 | 69.7 | 0.91 | 11.36 | 6.74 | 0.50 | |
| 10.0 | 82.6 | 62.8 | 0.43 | 7.55 | 19.34 | 2.04 | |
|
| |||||||
| ∗V60 | 5.0 | 126.0 | 96.1 | 0.45 | 14.20 | 15.04 | — |
| 7.5 | 102.5 | 79.0 | 0.45 | 13.15 | 13.35 | — | |
| 10.0 | 87.7 | 64.0 | 0.59 | 11.46 | 9.46 | — | |
(a) ND: not determined due to the break-up of the tablets; (b) ∗V60 is maize starch BP, the reference disintegrant used.