FIGURE 3.

Multivariate models to predict CCK EC₅₀ values in patient populations. (A) Actual and predicted CCK sensitivity (EC₅₀ values) among diabetic participants based on a model that included HDL cholesterol and glycated hemoglobin as predictor variables (line represents the unity line where the actual CCK EC₅₀ equals the predicted CCK EC₅₀; n = 35; r² = 0.26, P < 0.01). (B) Actual CCK sensitivity data by leukocyte cellular cholesterol values with plotting symbols for men (n = 43) and women (n = 69) in the entire population (lines represent predicted CCK EC₅₀ based on a model that included sex, leukocyte cellular cholesterol, and sex-by-leukocyte cellular cholesterol interaction). The overall r² value for the model was 0.29 (P < 0.001). Sex subgroupings without a cell cholesterol-by-sex interaction term included estimates of r² = 0.40 (P < 0.001) for women and r² = 0.06 (P = 0.12) for men. CCK, cholecystokinin; EC₅₀, concentration stimulating one-half of the maximal response.