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. 2017 Jun 7;106(2):447–456. doi: 10.3945/ajcn.117.156943

TABLE 2.

Correlations for CCK sensitivity and cellular cholesterol with serum biochemical markers in normal-weight, obese and morbidly obese, and diabetic patients1

BMI (kg/m2) <25 (normal weight)
 BMI >30 (obese and morbidly obese)
 Diabetic
Serum markers r P n r P n r P n
Correlations with CCK sensitivity (EC50 values)
 Triglycerides 0.4765* 0.0391* 19 0.0320 0.8311 47 0.1207 0.4899 35
 Serum cholesterol 0.1496 0.5411 19 −0.0717 0.6318 47 −0.0423 0.8094 35
 LDL cholesterol 0.0031 0.9900 19 0.0647 0.6765 47 0.0624 0.7258 34
 HDL cholesterol −0.2253 0.3537 19 −0.3441* 0.0179* 47 −0.3307#x2020 0.0523#x2020 35
 HbA1c 0.1351 0.5813 19 −0.1636 0.2717 47 0.3320#x2020 0.0514#x2020 35
Correlations with cellular cholesterol
 Triglycerides 0.7571* 0.0002* 19 −0.0318 0.8317 47 0.0880 0.6154 35
 Serum cholesterol 0.1898 0.4364 19 0.2099 0.1568 47 0.2795 0.1040 35
 LDL cholesterol 0.1509 0.5375 19 0.3339* 0.0267* 44 0.3476* 0.0440* 34
 HDL cholesterol −0.4756* 0.0396* 19 0.0204 0.8918 47 −0.0855 0.6255 35
 HbA1c 0.1370 0.5759 19 −0.1109 0.4580 47 0.3410* 0.0450* 35
1

The numbers of patients studied (n), Spearman correlation coefficients (r), and P values are shown. *Significant at P < 0.05 (for correlations with CCK sensitivity, these represent triglyceride concentrations in normal-weight participants and HDL-cholesterol concentrations in obese and morbidly obese participants; for correlations with cellular cholesterol, these represent triglyceride concentrations in normal-weight participants, LDL-cholesterol concentrations in obese and morbidly obese participants and in patients with diabetes, HDL-cholesterol concentrations in normal-weight participants, and HbA1c concentrations in patients with diabetes). †Trend toward significance (P value between 0.05 and 0.10) with limited sample sizes (for correlations with CCK sensitivity, these represent HDL-cholesterol and HbA1c concentrations in patients with diabetes). Spearman’s correlation test was used to obtain the r and P values. CCK, cholecystokinin; EC50, concentration stimulating one-half of the maximal response; HbA1c, glycated hemoglobin.