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A: Serum tHcy and Methionine in mice before and after bortezomib treatment (0.49/mg/kg/day, n=8). Error bars show SD. B: CBS Western blot of liver extracts from treated (B) and untreated mice (U). Control (C) is liver extract from Tg-hCBS Cbs−/− mouse. CBS activity is expressed in nmoles cystathionine formed/mg total soluble liver protein/hr.
