Table 3.
Association between SNPs and NIHL risk
| SNP | Genetic model | Genotype | Controls, n (%) | Cases, n (%) | P | OR(95%CI)a |
|---|---|---|---|---|---|---|
| rs1049216 | Additive | CC | 173(64.3) | 195(72.5) | 1.0 | |
| CT | 82(30.5) | 68(25.3) | 0.050 | 0.609(0.372–1.000) | ||
| TT | 14(5.2) | 6(2.2) | 0.032 | 0.246(0.069–0.886) | ||
| Dominant | CC | 173(64.3) | 195(72.5) | 1.0 | ||
| CT + TT | 96(35.7) | 72(27.5) | 0.014 | 0.551(0.343–0.885) | ||
| Recessive | CC + CT | 258(94.8) | 266(97.8) | 1.0 | ||
| TT | 14(5.2) | 6(2.2) | 0.047 | 0.277(0.078–0.986) | ||
| rs6948 | Additive | AA | 177(65.8) | 198(73.6) | 1.0 | |
| AC | 79(29.4) | 65(24.2) | 0.050 | 0.607(0.369–1.000) | ||
| CC | 13(4.8) | 6(2.2) | 0.089 | 0.328(0.091–1.185) | ||
| Dominant | AA | 177(65.8) | 198(73.6) | 1.0 | ||
| AC + CC | 92(34.2) | 71(26.4) | 0.020 | 0.568(0.352–0.916) | ||
| Recessive | AA + AC | 256(95.2) | 263(97.8) | 1.0 | ||
| CC | 13(4.8) | 6(2.2) | 0.128 | 0.373(0.105–1.327) | ||
| Risk genotypeb | 0 | 91(33.8) | 71(26.4) | 1.0 | ||
| 1 | 6(2.2) | 3(1.1) | 0.701 | 0.684(0.098–4.779) | ||
| 2 | 172(63.9) | 195(72.5) | 0.018 | 1.787(1.104–2.892) | ||
aadjusted for age, sex, education, marriage status, income, working time, noise exposure time, noise intensity exposure, CNE, telephone using time, music listening time, and time go to sleep
brs1049216 CC and rs6948 AA genotypes were classified as high-risk genotypes; the number represents the numbers of the two genotypes within the combined genotypes