Table 7.
FNT channels with unique central constriction region
| FNT subfamily | UniProt IDa (Organism) | Central constriction residuesb | CHI/CVV valuec |
|---|---|---|---|
| Unclassified | Q1Q4Z9 (Candidatus Kuenenia stuttgartiensis) | YFQS | CHI: −2.8 |
| YfdC-α | Q0G7B8 (Fulvimarina pelagi) | YLHT | CHI: −1.4 |
| YfdC-α | Q1YI18 (Aurantimonas manganoxydans) | YVHT | CHI: −1.0 |
| YfdC-α | I1ARB3 (Citreicella sp.) | YMHA | CHI: −0.8 |
| YfdC-β | K9AG69 (Brevibacterium casei) | FVHI | CHI: +8.3 |
| Unclassified | Q1PZF5 (Candidatus Kuenenia stuttgartiensis) | FIHV | CHI: +8.3 |
| NirC-γ | B9DL87, B9DLT5 (Staphylococcus carnosus) B9E993 (Macrococcus caseolyticus) E8SEZ7 (Staphylococcus pseudintermedius) E8SFH6 (Staphylococcus pseudintermedius) G5JLA8 (Staphylococcus simiae) I7JE48 (Staphylococcus equorum) K9AHL1, K9ANW4 (Staphylococcus massiliensis) J9HA25 (Staphylococcus sp.) and 6 more |
FFHY | CVV: 529 Ǻ3 |
aThe unique UniProt Accession ID is given
bThe four residues that form central constriction site within the channel. They correspond to F75 from TM2a, F202 from TM5a, H209 from S-loop and A212 from TM5b of the formate channel (PDB ID: 3KCU)
cCalculation of Cumulative Hydropathy Index (CHI) and Cumulative vdw Volume (CVV) are described in the text