Table 1.
Characteristic of selected SNPs
| SNP ID | Gene or nearby region | Location | Position | Traits | OR [95% CI] | References |
|---|---|---|---|---|---|---|
| rs3751812 | FTO | 16q12.2 | Intron 1 | Obesity | 1.42 [1.33–1.52] | Frayling et al., 2007 [60] |
| rs8050136 | FTO | 16q12.2 | Intron 1 | T2DM; obesity | 1.22 [1.07–1.40] 1.45 [1.09–1.93] | Liu et al., 2010 [26] |
| rs9939609 | FTO | 16q12.2 | Intron 1 | T2DM; obesity | 1.19 [1.04–1.37]; 1.39 [1.04–1.85] | Liu et al., 2010 [26] |
| rs10811661 | CDKN2A/B | 9p21.3 | Intergenic | T2DM | 1.20 [1.14–1.25] | Zeggini et al., 2007 [27] |
| rs2383208 | CDKN2A/B | 9p21.3 | Intergenic | T2DM | 1.34 [1.27–1.41] | Takeuchi et al., 2009 [28] |
| rs1111875 | HHEX | 10q23.33 | 3′-UTR | T2DM | 1.21 [1.15–1.28] | Takeuchi et al., 2009 [28] |
| rs5015480 | HHEX | 10q23.33 | Intergenic | T2DM | 1.17 [1.11–1.24] | Zegginietal., 2008 |
| rs13266634 | SLC30A8 | 8q24.11 | Exon 8, missense | T2DM | 1.16 [1.10–1.22] | Rung et al., 2009 [29], Takeuchi et al., 2009 [28] |
| rs4506565 | TCF7L2 | 10q25.3 | Intron 3 | T2DM | 1.36 [1.20–1.54] | Wellcome Trust Case Control Consortium (2007) [30] |
| rs7903146 | TCF7L2 | 10q25.3 | Intron 4 | T2DM | 1.49 [1.39–1.59] | Timpson et al., 2009 [31] |
| rs4402960 | IGF2BP2 | 3q27.2 | Intron 2 | T2DM | 1.14 [1.08–1.21] | Takeuchi et al., 2009 [28] |
| rs5215 | KCNJ11 | 11p15.1 | Exon 1 | T2DM | 1.16 [1.09–1.23] | Zeggini et al., 2008 [12] |
| rs7756992 | CDKAL1 | 6p22.3 | Intron 5 | T2DM | 1.20 [1.13–1.27] | Steinthorsdottir et al., 2007 [32] |
| rs4712523 | CDKAL1 | 6p22.3 | Intron 5 | T2DM | 1.27 [1.21–1.33] | Takeuchi et al., 2009 [28] |
| rs9465871 | CDKAL1 | 6p22.3 | Intron 5 | T2DM | 1.18 [1.04–1.34] | Wellcome Trust Case Control Consortium (2007) [30] |
| rs7961581 | nearTSPAN8/LGR5 | 12q21.1 | Intergenic | T2DM | 1.09 [1.06–1.12] | Zeggini et al., 2008 [12] |
| rs864745 | JAZF1 | 7p15.2-p15.1 | Intron 1 | T2DM | 1.10 [1.07–1.13] | Zeggini et al., 2008 [12] |
| rs12779790 | nearCDC123/CAMK1D | 10p13 | Intergenic | T2DM | 1.11 [1.07–1.14] | Zeggini et al., 2008 [12] |
| rs10490072 | BCL11A | 2p16.1 | 3′ ofgene | T2DM | 1.05 [1.03–1.08] | Zeggini et al., 2008 [12] |
| rs10923931 | NOTCH2 | 1p13-p11 | Intron 5 | T2DM | 1.13 [1.08–1.17] | Zeggini et al., 2008 [12] |
| rs7578597 | THADA | 2p21 | Exon 24, missense | T2DM | 1.15 [1.10–1.20] | Zeggini et al., 2008 [12] |
| rs2025804 | LEPR | 1p31 | Intron 2 | BMI | Traurig et al., 2012 [33] | |
| rs2641348 | ADAM30 | 1p12 | Exon 1, missense | T2DM | 1.10 [1.06–1.15] | Zeggini et al., 2008 [12] |
| rs9472138 | near VEGFA | 6p21.1 | Intergenic | T2DM | 1.06 [1.04–1.09] | Zeggini et al., 2008 [12] |
| rs1042714 | ADRB2 | 5q31-q32 | Exon 1, missense | T2DM | 0.56 [0.36–0.91] | Pinelli et al., 2006 [34] |
| rs4994 | ADRB3 | 8p12 | Exon 1, missense | T2DM | 1.27 [1.07–1.51] | Jing et al., 2012 [35] |
| rs1799883 | FABP2 | 4q28-q31 | Exon 2, missense | T2DM | 1.29 [1.08–1.49] | Qiu et al., 2014 [8] |
| rs1801282 | PPARG | 3p25 | Exon 4, missense | T2DM | 1.14 [1.08–1.20] | Scott et al., 2007 [11] |
| rs8192678 | PPARGC1A | 4p15.1 | Exon 8, missense | T2DM | 1.07 [1.00–1.15] | Barroso et al., 2006 [37] |
| rs780094 | GCKR | 2p23 | Intron 16 | T2DM | 0.71 [0.58–0.85] | Onuma et al., 2010 [38] |
| rs7944584 | MADD | 11p11.2 | Intron 25 | T2DM | 1.63 [1.32–2.02] | Hu et al., 2010 [39] |
| rs1153188 | DCD-VDAC1P5 | 12q13 | Intergenic | T2DM | 1.08 [1.05–1.11] | Zeggini et al., 2008 [12] |