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. 2017 Jul 25;11:369. doi: 10.3389/fnhum.2017.00369

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Copyright © 2017 Motch Perrine, Stecko, Neuberger, Jabs, Ryan and Richtsmeier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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3D reconstructions of high resolution HRμCT images of skull and HRMRM images of brain of E17.5 embryos superimposed to reveal structural associations. (A) Fgfr2^+/+ unaffected littermate of the Apert syndrome mouse model; (B) Fgfr2^+/S252W Apert syndrome mouse model; (C) Fgfr2c^+/+ unaffected littermate of the Crouzon syndrome mouse model; (D) Fgfr2c^C342Y/+ Crouzon syndrome mouse model. Scale bar = 1 mm. For details of image acquisition see Section Materials and Methods.