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. 2017 Jul 25;11:369. doi: 10.3389/fnhum.2017.00369

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Copyright © 2017 Motch Perrine, Stecko, Neuberger, Jabs, Ryan and Richtsmeier.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Brain (in blue) and skull (in red) linear distances whose association was statistically significantly different between Fgfr2^+/S252W Apert syndrome mice and Fgfr2^+/+ unaffected littermates at E17.5 pictured on HRMRM and HRμCT reconstruction of a Fgfr2^+/+ unaffected littermate (A, lateral view; B, superoinferior view). The two brain metrics (BR29 and BR34; see Supplementary Table 2) were in included in 71 of 139 (~51%) of the correlations that were significantly different between Fgfr2^+/S252W Apert syndrome mice and Fgfr2^+/S252W Apert syndrome mice and Fgfr2^+/+ unaffected littermates. Scale bar = 1 mm.