Table 1.

lncRNAs associated with β cell function and type 1 diabetes

lncRNAs	Function	Reference
MEG3	Regulates β cell identity and function via insulin production and apoptosis in mouse MIN6 cells and isolated mouse islets	You et al. 2016 [22]
HI-LNC25	Positively regulates GLIS3 (which contains both T1D and T2D risk variants) in EndoC-βH1 human β cell line	Moran et al. 2012 [18]
βlinc1 (HI-LNC15)	Regulates β cell identity and function in mouse MIN6 cells and EndoC-βH1 human β cell line; also regulates its neighboring gene NKX2.2 (an islet transcription factor).	Arnes et al. 2016 [23]
TUNAR (HI-LNC78)	Knockdown of TUNAR leads to impaired glucose-stimulated insulin secretion in human islets	Akerman et al. 2017 [24]
PLUT (HI-LNC71)	Regulates transcription of PDX1, a key pancreatic β cell transcriptional regulator, in EndoC-βH1 cells, primary islet cells, mouse β cell line MIN6	Akerman et al. 2017 [24]
MALAT1	Upregulation of MALAT1 is associated with microvascular dysfunction (diabetic retinopathy) in STZ-induced diabetic rats and db/db mice	Liu et al. 2014 [20]
TUG1	Downregulation of lncRNA TUG1 expression increased apoptosis and reduced insulin secretion in mouse β cells	Yin et al. 2015 [25]