TABLE 1.

Targeted Therapies Report Card

• Responses dramatic but usually short lived – many resistance mechanisms identified

• Target mutations can be matched to precision drug in only small, but growing, percentages of patients

• Long term survival improved at best in a subset of the subset of patients

• Experience has revealed that tumors behave in patients in ways far more complicated than anticipated from animals and in vitro models

• Using genomics to guide therapy is complicated and expensive because massive amounts of data must be accumulated and interpreted.