Fig. 5.

Immunoglobulin E (IgE)–dependent local mast cell activation induced by activation with a single antigen can enhance resistance to the lethality of Russell’s viper venom (RVV). (A) Experimental outline. (B) Body temperature and (C) Survival of C57BL/6 mice treated with 3 subcutaneous injections of saline alone or containing 50 ng anti-dinitrophenyl (anti-DNP) IgE, IgG1 or IgG2b antibody and challenged 18 hours later with 2 subcutaneous injections, each containing 37.5 µg RVV and 0.5 µg dinitrophenylated human serum albumin (DNP-HSA). Data were pooled from two to five independent experiments (n = 10 to 25/group). P values: Student t test (B); Mantel-Cox test (C). Abbreviation: PBS, phosphate-buffered saline.[This is a reproduction of Figure 5 from Starkl P, Marichal T, Gaudenzio et al. IgE antibodies, FcεRIα and IgE-mediated local anaphylaxis can limit snake venom toxicity. J Allergy Clin Immunol 2016;137:246-57.e11. (reference 93), reprinted with the permission of the publisher, Elsevier.]