Table 2.

Future questions on macrophage inducible C-type lectin (Mincle)’s immune functions.

1.	Which are the physicochemical properties of Helicobacter pylori, Fonsecaea monophora, Leishmania major, Candida albicans, and Pneumocystis carinii ligands recognized by Mincle?
2.	Can the promiscuity of Mincle’s ligand interactions be explained by structural analogies between ligands?
3.	Is Mincle recruited to the phagocytic synapse together with other receptors?
4.	Are Mincle SNPs associated with increased susceptibility to cancers and autoimmune diseases?
5.	Is Mincle involved in autoimmunity in the absence of respective ligands during the induction phase?
6.	Is targeting Mincle a strategy to cure infections, cancers, and autoimmune diseases?
7.	Is Mincle playing a role in sterile inflammation?