Table 5.
Logistic regression analysis of rs1470527 in bone morphogenetic protein 5 genotype frequencies and risk of osteoarthritis with osteoarthritis of the knee and controls
| Cases | Controls | TT versus CC | CT versus CC | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n=499 | CC | CT | TT | n=458 | CC | CT | TT | Adjusted ratio | 95% CI | Adjusted ratio | 95% CI | |
| Age group | ||||||||||||
| ≤55 | n=206 | 39 (18.93) | 100 (48.54) | 67 (32.52) | n=206 | 107 (51.94) | 46 (22.33) | 50 (24.27) | 3.7 | 2.19-6.17 | 7.6 | 4.5-12.93 |
| >55 | n=293 | 39 (13.31) | 187 (63.82) | 67 (22.87) | n=255 | 158 (61.96) | 44 (17.25) | 53 (20.78) | 5.12 | 0.9-2.3 | 17.21 | 10.68-27.83 |
| Gender | ||||||||||||
| Male | n=187 | 35 (18.71) | 88 (47.06) | 64 (34.22) | n=168 | 84 (50.0) | 39 (23.21) | 45 (26.79) | 3.41 | 1.9-5.9 | 5.41 | 3.14-9.3 |
| Female | n=312 | 43 (13.78) | 199 (63.78) | 70 (22.43) | n=290 | 181 (62.41) | 51 (17.59) | 58 (20.0) | 5.1 | 3.13-8.22 | 16.42 | 10.44-25.83 |
Data presented as n (%) of patients. Adjusted for the other covariate presented in this table and for BMI using a logistic regression model for each stratum. CI: Confidence interval, BMI: Body mass index