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. Author manuscript; available in PMC: 2017 Dec 22.
Published in final edited form as: J Med Chem. 2016 Dec 2;59(24):11148–11160. doi: 10.1021/acs.jmedchem.6b01450

Figure 3.

Figure 3

Overlaid 2D TOCSY NMR spectra of pyrimidine residues of TAR (A) with increasing concentrations of 2. Indicated are free TAR (black) and TAR:2 ratio of 1:1 (green), 1:2 (light blue), 1:3 (dark blue), and 1:5 (red). Arrows indicate the direction of chemical shift changes upon addition of 2. (B) Secondary structure of 29nt TAR hairpin with bases perturbed in the presence of 2 highlighted with red circles.