Figure 1. Active-like conformation of AT₂R.

a, Overall receptor architecture. Cpd 1 is shown as spheres with carbon atoms in magenta, nitrogen in blue, oxygen in red, and sulfur in yellow. Membrane boundaries as defined by the OPM web server (www.opm.phar.umich.edu) are shown as red lines. b–e, Structural comparison of the active-like AT₂R (cyan) with the inactive AT₁R (green, PDB 4YAY), and active G protein-bound β₂AR (yellow, PDB 3SN6) viewed from within the membrane (b), the extracellular side (d), and the intracellular side with helix VIII removed (e). The magnified region in (c) shows details of microswitches in the conserved motifs. The backbone of AT₂R is shown in cyan cartoon, while distinct inactive position of AT₁R helix VII is shown in green. Red arrows indicate conformational changes associated with receptor activation.