Protective effect of glycyrrhizin on ERK protein expression in myocardial I/R injury rats. (A) Protective effect of glycyrrhizin on p-ERK protein expression using western blotting analysis and (B) statistical analysis of p-ERK protein expression in rats with myocardial I/R injury. Data are presented as the mean ± standard deviation. **P<0.01 vs. the Sham group; ##P<0.01 vs. the NS group. I/R, ischemia/reperfusion; p-ERK, phosphorylated extracellular signal-regulated kinase; NS, myocardial I/R injury + non-treated group; 2 mg/kg, myocardial I/R injury + pre-treatment with 2 mg/kg glycyrrhizin group; 4 mg/kg, myocardial I/R injury + pre-treatment with 4 mg/kg glycyrrhizin group; 10 mg/kg, myocardial I/R injury + pre-treatment with 10 mg/kg glycyrrhizin group.