Figure 3.

Cytokines production in synovium and serum affected by the modification of miR-34a function. (A) Cytokine mRNA expression of in the synovium of joints from the three groups. (n=6 per group). (B) Cytokine production in the serum of the three groups. miR-34a agomir, miR-34a antagomir, and CIA model mice were sacrificed on day 44. Results are means ± SEM. All data are representative of three independent experiments. *P<0.05 **P<0.01, ***P<0.001 for comparisons between the treatment group and the CIA model group.