Correlation analysis of HCV RNA and ALT with different IgM+B cell subsets in patients with CHC. (A) Correlation of HCV RNA with CD27-CD10+IgM+B, CD27-IgD+IgM+B, CD27-CD38+IgM+B cells, CD27+CD38+IgM+B and CD27+CD21-IgM+B cells. (B) Correlation of ALT with CD27-CD10+IgM+B cells, CD27-IgD+IgM+B cells, CD27-CD38+IgM+B cells, CD27+CD38+IgM+B cells, and CD27+CD21-IgM+B cells. HCV, hepatitis C virus; ALT, alanine transaminase; CD, cluster of differentiation; Ig, immunoglobulin.