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. 2017 Jun 24;7(9):2443–2451. doi: 10.7150/thno.18290

Figure 1.

Figure 1

High fat diet (HFD) changed the composition and NR activity of gut microbiota in hamsters. (A) Chemical structure of BBR; (B) the levels of total cholesterol (TC), triglycerides (TG) and low-density-lipoprotein cholesterol (LDL-C) significantly increased in the HFD-fed hamsters (6 weeks), as compared to that in hamsters fed with normal diet (ND) (***P<0.001, n=6); (C) NR activity of intestinal bacteria elevated in HFD-fed hamsters (HFD vs ND, **P<0.01, n=6); (D) Feeding hamsters with HFD for six weeks changed gut microbiota composition in hamsters (n=4 for each group) with an increase in the proportion of NR-producing bacteria; (E) NR activity increased significantly in the in vitro single bacterial cultures (Enterococcus faecium, Bacteroides fragilis) in the presence of the anaerobic medium broth (0.6 ml/1 ml) in culture medium for 24 hrs.