Table II.
Biomarkers and the changing trend of CCl4-liver fibrosis in rat urine at 12 weeks.
| Metabolite No. | Var ID (Primary) | Possible compounds | RT, min | VIP | Biomarker content in MG |
|---|---|---|---|---|---|
| 1 | 77 | 2-hydroxy butyric acid | 12.9871 | 2.48859 | Increasea |
| 2 | 114 | isoleucine | 15.0919 | 1.29507 | Increasea |
| 3 | 134 | N-acetyl-β-alanine | 16.9516 | 2.53192 | Decreasea |
| 4 | 314 | cytidine | 24.8217 | 2.38341 | Decreasea |
| 5 | 491 | corticoid | 34.8550 | 2.96963 | Increasea |
519 peaks of the GC/MS spectra of the model and control groups were screened, corresponding to the number of the substance in serum when the VarID was imported into the software, VIP values >1.0 were selected as changed metabolites. From this, 5 metabolites in the urine were demonstrated to be significantly altered. CCl4, carbon tetrachloride; RT, retention time of the substance; VIP, variable importance projection; MG, model group.
a
P<0.05 vs. control group.