Figure 1.

Schematic of complex glycans in the interplay between virus and host. Shown in the figure (on the left) is a schematic of a virus surface glycoprotein (such as influenza A virus hemagglutinin) that recognized glycans on the host cell surface as their primary receptors for viral attachment and entry. The viral surface protein is in itself glycosylated and depending on the site of glycan occupancy, the glycosylation would impact the binding of this protein to the host-cell glycan receptor. Shown on the right is a schematic of glycan on the surface of virus envelop proteins (such as dengue) interacting with GBP anchored on the host cell. This interaction could either be beneficial for the virus wherein it plays a role in viral attachment and entry into a cell capable of promoting the productive infection or it could be beneficial to the host wherein antigen presenting cells could uptake the virus and prime the host immune response.