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. Author manuscript; available in PMC: 2017 Jul 25.
Published in final edited form as: Cell Rep. 2017 Jun 6;19(10):2014–2025. doi: 10.1016/j.celrep.2017.05.037

Figure 4.

Figure 4

Maternal mTORC1 inhibition by rapamycin rescues osteopetrosis and alopecia in the offspring. (A) Western blot for mTORC1 signaling in day 10 lactating mammary glands. (B) Lactating moms were treated with rapamycin (rapa) or vehicle every other day for 21 days since parturition. Images of P21 pups, representative of 3 independent experiments. (C) Serum CTX-1 (n=5). (D) μCT images. (E-I) μCT quantification (n=4). (J-M) Gene expression for enzymes (J) and transcription factors (K) regulating cholesterol synthesis, cytokines (L) and enzymes (M) regulating inflammation in day 10 lactating mammary glands (WT n=3; KO n=4; KO+Rapa n=3).