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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Biotechnol Bioeng. 2017 May 18;114(9):2121–2130. doi: 10.1002/bit.26335

Table I. Animal Experimental Design.

Group name Animal number (n) Schwann cell (SC) description Number of cells transplanted
Untreated 8 Untreated (normal culture conditions) 1×106 SCs
GDNF-on 8 Transduced with constitutively active lentivirus containing transgene GDNF 1×106 SCs
GDNF-tet-on (DOX) 8 Transduced with tetracycline inducible lentivirus containing transgene GDNF; Doxycycline for 6 weeks in vivo 1×106 SCs
GDNF-tet-on (no DOX) 8 Transduced with tetracycline inducible lentivirus containing transgene GDNF; No Doxycycline 1×106 SCs
GDNF-tet-on (1wk DOX) 8 Transduced with tetracycline inducible lentivirus containing transgene GDNF; Doxycycline for 1 week in vivo 1×106 SCs
ANA 8 No cells added None

All animals were harvested for nerve tissue 6 weeks following procedures.