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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Virology. 2017 May 31;508:199–212. doi: 10.1016/j.virol.2017.05.016

Fig. 5. The α4β7 integrin binds to deglycosylated (poorly glycosylated) gp140 HIV-1 envelope protein, regardless of the type of glycosylation or the HIV-1 subtype.

Fig. 5

A, α4β7 binding with gp140 proteins of five strains of HIV-1 (BG505, FV40007, FV40100, JR-FL, and SF162). B, α4β7 binding activity of the JR-FL gp140 proteins produced in three different cell lines (293F, CHO, and GnTI−). α4β7 binding activity in the absence of any mAb inhibitor was shown in light blue bars. Specificity of V1V2 binding to α4β7 was determined by the decrease in relative luminescence in the presence of the α4β7-specific HP2/1 mAb (dark blue bars). Data are shown as mean +/− SEM and are representative of at least three independent assays and three different preparations of proteins, done in triplicate.