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. 2017 Jun 22;14(2):1271–1276. doi: 10.3892/etm.2017.4642

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Copyright: © Yao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Steroid hormone biosynthetic pathways in ovary. In the ovarian theca cells androgen formation is stimulated by LH via the steroidogenic pathway. Androgen biosynthesis following stimulation by LH is modulated by cytochrome P450c17, which possesses both 17-hydroxylase and 17,20-lyase activities in theca cells. Androstenedione formed in theca cells is also taken up by granulosa cells, where it can contribute to the formation of estrogens. Androstenodione in theca cells is converted to testosterone, which leads to hyperandrogenism. Insulin also stimulates androgen production by theca cells. LH, luteinizing hormone.