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. 2017 Jun 16;14(2):1045–1050. doi: 10.3892/etm.2017.4624

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Copyright: © CUI et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — MAPK12 is a direct target of miR-187. (A) Putative miR-187 binding site in 3′-UTR region of MAPK12 and interspecies conservation of seed matching sequences. (B) Smad3 mRNA level was inversely correlated with miR-187 level in osteosarcoma tissues (Spearman correlation analysis). (C) Protein level of Smad3 was detected by western blotting in U2OS cells transfected with miR-187 mimics along with corresponding controls. (D) Protein level of MAPK12 in osteosarcoma tissues and normal tissues by western blotting.