Figure 3.

Effects of IL-32α on the (A) mRNA and (B) protein expression levels of ABCA1, ABCG1, LXRα and PPARγ in ox-LDL-stimulated THP-1 macrophages, as determined by quantitative polymerase chain reaction and western blot analysis, respectively. THP-1 macrophages were pretreated with different concentrations of (20, 50 and 100 ng/ml) of IL-32α for 6 h, followed by incubation with ox-LDL for 72 h. Data are expressed as the mean ± standard deviation (n=3). *P<0.05. IL-32α, interleukin-32α; ox-LDL, oxidized low-density lipoprotein; ABC, ATP-binding cassette transporter; LXRα, liver X receptor α; PPARγ, peroxisome proliferator-activated receptor γ.