Table 2.
Total DMRs | Intersected CGIs | DMRs Intersecting Genes* | ||
---|---|---|---|---|
MBD-seq | 769 | 43 | 135 | |
Methylation loss | 599 | 43 | 89 | |
Methylation gain | 170 | 0 | 46 | |
MeDIP-seq | 1771 | 57 | 424 | |
Methylation loss | 1101 | 55 | 219 | |
Methylation gain | 670 | 2 | 205 | |
Overlap | 224 | 25 | 23 | |
Methylation loss | 198 | 25 | 18 | |
Methylation gain | 26 | 0 | 5 | |
DMRs: Differentially methylated regions. These include adjacent 100bp windows in which DNA methylation levels are significantly different between MAM-treated rats and Saline-control rats at FDR<0.05.
CGI: CpG island. Numbers shown indicate how many DMRs fall within a CGI; in some cases multiple DMRs fall within the same CGI.
The number of DMRs that intersect with one (or more) annotated genes (including those of uncertain function, e.g. LOC genes)