Table 5.
Change in Antiribosomal Selectivity (Selectivity Quotient) with Respect to the Parent Neomycin.
| Entry | Compound | Selectivity Quotient
(SelQ)a
|
||
|---|---|---|---|---|
| Mit13 | A1555G | Cyt 14 | ||
| 1 | paromomycin 4 | 15.47 | 12.14 | 0.28 |
| 2 | 21 | 8.09 | 25.05 | 2.24 |
| 3 | 30 | 7.51 | 5.14 | 3.20 |
| 4 | 22 | 6.00 | 3.37 | 1.26 |
| 5 | 28 | 4.5 | 176 | 1.1 |
| 6 | 11 | 0.58 | 12.55 | 1.89 |
| 7 | 5 | 7.66 | 65.18 | 0.75 |
| 8 | 26 | 6.88 | 13.28 | 1.12 |
| 9 | 37 | 0.26 | 13.14 | 0.51 |
| 10 | 40 | 0.42 | 3.37 | 0.05 |
| 11 | 38 | 0.24 | 2.27 | 0.03 |
SelQ = selectivity derivative/selectivity parent.