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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2017 Jan 17;52(2):220–233. doi: 10.1080/10409238.2016.1276882

Figure 4. CircRNA sequesters proteins during cardiac senescence.

Figure 4

Circ-FOXO3 expression is able to bind to the transcription factors E2F1, ID1, and HIF1α and inhibit their translocation into the nucleus. The lack of nuclear translocation decreases the transcription of stress response factors. Cic-FOXO3 is also able to bind to FAK and inhibit its localization into the mitochondria. Reduced FAK levels in the mitochondria decrease the ability for cells to re-establish redox homeostasis. A color version of the figure is available online.