Recommendation: We suggest using protocolized methods for liberation from mechanical ventilation in patients with ARDS (Grade 2D,Strength of recommendation “weak recommendation” / Quality of evidence “Very low”).

●Supplementary statements: When developing protocols for liberation, the level of knowledge and skills of the personnel who apply the protocol in each facility must be taken into account. Education and training regarding mechanical ventilation are required, especially for non-physician staff members. A previous meta-analysis [76] showed a reduction in the duration of mechanical ventilation for patients in medical, surgical and medical/surgical ICUs but not in a neurological ICU.