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. 2017 Jul 25;12:55. doi: 10.1186/s13000-017-0634-3

Table 2.

22 fusion genes screened using the multi-fusion gene F-qRT-PCR assay system

Fusion genes Also known as Frequently associated diseases
RUNX1-RUNX1T1 AML1-ETO AML M2
AML1-MDS1/EVI1 AML
AML1-MTG16 RUNX1–CBFA2T3 AML, MDS
BCR-ABL CML, ALL
CBFβ-MYH11 AML
DEK-CAN AML, MDS
E2A-HLF Pre-B ALL
E2A-PBX1 Pre-B ALL
MLL-AF10 KMT2A-MLLT10 AML M5/M4
MLL-AF4 KMT2A-AFF1 ALL, AML M4/M5
MLL-AF6 KMT2A-MLLT4 AML M4/M5, T-cell ALL
MLL-AF9 KMT2A-MLLT3 AML M5a
MLL-ELL KMT2A-ELL AML M4/M5
MLL-ENL KMT2A-MLLT1 AML M4/M5, B-cell ALL
NPM-MLF AML M2/4/6, MDS
PLZF-RARα AML M3 (APL)
PML-RARα AML M3 (APL)
STAT5b-RARα AML M3 (APL)
FIP1L1-PDGFRA CMML, CEL
TEL-PDGFRB CMML, CEL
SIL-TAL1 T-cell ALL
TEL-AML1 ETV6-RUNX1 B-cell ALL

AML acute myeloid leukemia, ALL acute lymphocytic leukemia, CML chronic lymphocytic leukemia, MDS myelodysplastic syndromes, APL acute promyelocytic leukemia, CMML chronic myelomonocytic leukaemia, CEL chronic eosinophilic leukemia