Table 2.
Fusion genes | Also known as | Frequently associated diseases |
---|---|---|
RUNX1-RUNX1T1 | AML1-ETO | AML M2 |
AML1-MDS1/EVI1 | AML | |
AML1-MTG16 | RUNX1–CBFA2T3 | AML, MDS |
BCR-ABL | CML, ALL | |
CBFβ-MYH11 | AML | |
DEK-CAN | AML, MDS | |
E2A-HLF | Pre-B ALL | |
E2A-PBX1 | Pre-B ALL | |
MLL-AF10 | KMT2A-MLLT10 | AML M5/M4 |
MLL-AF4 | KMT2A-AFF1 | ALL, AML M4/M5 |
MLL-AF6 | KMT2A-MLLT4 | AML M4/M5, T-cell ALL |
MLL-AF9 | KMT2A-MLLT3 | AML M5a |
MLL-ELL | KMT2A-ELL | AML M4/M5 |
MLL-ENL | KMT2A-MLLT1 | AML M4/M5, B-cell ALL |
NPM-MLF | AML M2/4/6, MDS | |
PLZF-RARα | AML M3 (APL) | |
PML-RARα | AML M3 (APL) | |
STAT5b-RARα | AML M3 (APL) | |
FIP1L1-PDGFRA | CMML, CEL | |
TEL-PDGFRB | CMML, CEL | |
SIL-TAL1 | T-cell ALL | |
TEL-AML1 | ETV6-RUNX1 | B-cell ALL |
AML acute myeloid leukemia, ALL acute lymphocytic leukemia, CML chronic lymphocytic leukemia, MDS myelodysplastic syndromes, APL acute promyelocytic leukemia, CMML chronic myelomonocytic leukaemia, CEL chronic eosinophilic leukemia