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. 2017 Jul 25;18:354. doi: 10.1186/s12859-017-1753-2

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — a An example of a genomic locus (chr1:1,145,478-1,145,614) in which each row corresponds to a sequencing read. Black and white circles represent methylated and unmethylated CpGs respectively. Note that some CpG measurements are missing. b The four epialleles that are inferred from the observed sequencing reads. c The Akaike Information Criterion score versus the total number of epialleles. The inferred number of epialleles corresponds to the minimum AIC score. d The proportion of observed reads attributed to each epiallele after marginalisation over the parameter w (see main text for details)