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. 2017 Jul 25;10:31. doi: 10.1186/s13047-017-0214-5

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Calculation of direct and indirect effects of change in body weight on change in functional limitation. Values are standardised β coefficients: (a) direct effect of change in body weight on functional limitation, (b) indirect effect of change in body weight, mediated by change in midfoot pressure. (*) Direct effect, (**) Indirect effect. The total effect of change in body weight on functional limitation is therefore the sum of the direct and indirect effects, i.e. total impact is 0.374 + 0.102 = 0.476