Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 25;19:175. doi: 10.1186/s13075-017-1363-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 3 — Supplemental intra-articular injection of wild-type alpha-2-macroglobulin (wt-A2M) and its variants CYT-98 and CYT-108 attenuates cartilage degeneration. a Strong Safranin O staining and a relatively smoother surface were detected in the articular cartilage from the animals treated with wt-A2M and its variants as compared to PBS-treated controls. b The Osteoarthritis Research Society International grading score indicated that cartilage damage was most severe in rats that underwent anterior cruciate ligament transection (ACLT) and PBS treatment, while cartilage in rats that underwent sham operation had the least damage. Cartilage damage was further reduced in the rats that received the high dose of the variants of A2M as compared to the rats that received the low dose of the variants of A2M. Values are the mean ± SD. ^#Compared with ACLT + PBS, P < 0.05; ^*compared with sham, P < 0.05; ^€compared with ACLT + A2M, P < 0.05