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. 2017 Jul 25;19:175. doi: 10.1186/s13075-017-1363-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Intra-articular injection of wild-type alpha-2-macroglobulin (wt-A2M) and its variants CYT-98 and CYT-108 leads to a thinner synovial membrane. a Hematoxylin/eosin staining indicates the synovium depicted with 1–2 cell layers of synoviocytes in the sham animals. Synovial hyperplasia is seen in the PBS-treated animals with the thicker synovial membranes, whereas the animals treated with A2M and its variants had thinner synovial membranes compared with the PBS-treated animals. Semi-quantified data are shown (b). ^#Compared with anterior cruciate ligament transection (ACLT) + PBS, P < 0.05; *compared with sham, P < 0.05; &compared with ACLT + A2M, P < 0.05; ^€compared with ACLT + 98-2-L, P <0.05; ^βcompared with ACLT + 98-2-H, P < 0.05; ^αcompared with ACLT + 108-2-L, P < 0.05