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. 2017 Jul 25;17:517. doi: 10.1186/s12879-017-2627-y

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Immunological recovery since cART initiation among HIV-infected patients in the German ClinSurv HIV Cohort, 1999-2013. (a) Profile plot of CD4+ cell count. (b) Profile plot of CD8+ cell count. (c) Profile plot of CD4:CD8 ratio. (d) Profile plot of viral load. The best-fitting model of CD4+ cells count is FP2 (0, 0.5) for subjects who remained free of TB and is FP2 (−1,1) for subjects who developed TB. Irrespective to TB development, the best-fitting model of CD8+ cells count is FP2 (−0.5, −0.5)], of CD4:CD8 ratio is FP2 (−0.5, −0.5), and of viral load is FP2 (−2, −0.5). No measurements were included after TB diagnosis. TB: tuberculosis; FP2: second-degree fractional polynomial model