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. 2017 Jul 25;17:517. doi: 10.1186/s12879-017-2627-y

Table 1.

Characteristic of cART-treated HIV-infected patients in the German ClinSurv HIV Cohort, 1999-2013

Demographic and clinical characteristic of HIV patients, N = 10,671 (100%) HIV-infected patients who remained free of TB, N = 10,532 (98.7%) HIV-infected patients developing TB, N = 139 (1.3%) P value
Female sex 2388 (22.5%) 45 (31.5%) 0.01b
Age at time of cART initiation
 Median (IQR), years 38.0 (31 – 45) 36.5 (31 – 45) 0.8c
Geographical origin
 Germany 7289 (70.1%) 60 (42.9%) <0.001b
 Sub-Saharan Africa 1344 (12.9%) 50 (35.7%)
 South−/Southeast Asia 273 (2.7%) 10 (7.1%)
 Others 1486 (14.3%) 20 (14.3%)
HIV-transmission routes
 MSM 5377 (56.9%) 49 (36.6%) <0.001b
 IDUs 886 (9.4%) 8 (6.0%)
 Others 3186 (33.7%) 77 (57.4%)
Calendar year of cART initiation <0.001b
 1999-2002 2524 (23.9%) 56 (24.2%)
 2003-2008 4531 (43.1%) 58 (43.0%)
 2009-2013 3477 (33.0%) 25 (32.8%)
Baseline CD4+ counta
 Median (IQR), cells per μl 285 (173 – 413) 168 (80 - 326) 0.1c
Baseline CD8+ counta
 Median (IQR), cells per μl 900 (602 – 1297) 846 (609 – 1364) 0.8c
Baseline CD4:CD8 ratioa
 Median (IQR) 0.3 (0.2 – 0.5) 0.2 (0.1 – 0.3) 0.3c
Baseline viral loada
 Median (IQR), log10 copies per ml 4.6 (3.6 – 5.2) 4.9 (3.7 – 5.1) 0.06c

cART combination antiretroviral therapy, TB tuberculosis, IQR interquartile range, MSM men who have sex with men, IDU injecting drug users

aBaseline was defined as the measurements taken at the date of cART initiation

bObtained using a χ2 test for difference in proportion

cObtained using a non-parametric K-sample test on the equality of medians