Table 1.
Demographic and clinical characteristic of HIV patients, N = 10,671 (100%) | HIV-infected patients who remained free of TB, N = 10,532 (98.7%) | HIV-infected patients developing TB, N = 139 (1.3%) | P value |
---|---|---|---|
Female sex | 2388 (22.5%) | 45 (31.5%) | 0.01b |
Age at time of cART initiation | |||
Median (IQR), years | 38.0 (31 – 45) | 36.5 (31 – 45) | 0.8c |
Geographical origin | |||
Germany | 7289 (70.1%) | 60 (42.9%) | <0.001b |
Sub-Saharan Africa | 1344 (12.9%) | 50 (35.7%) | |
South−/Southeast Asia | 273 (2.7%) | 10 (7.1%) | |
Others | 1486 (14.3%) | 20 (14.3%) | |
HIV-transmission routes | |||
MSM | 5377 (56.9%) | 49 (36.6%) | <0.001b |
IDUs | 886 (9.4%) | 8 (6.0%) | |
Others | 3186 (33.7%) | 77 (57.4%) | |
Calendar year of cART initiation | <0.001b | ||
1999-2002 | 2524 (23.9%) | 56 (24.2%) | |
2003-2008 | 4531 (43.1%) | 58 (43.0%) | |
2009-2013 | 3477 (33.0%) | 25 (32.8%) | |
Baseline CD4+ counta | |||
Median (IQR), cells per μl | 285 (173 – 413) | 168 (80 - 326) | 0.1c |
Baseline CD8+ counta | |||
Median (IQR), cells per μl | 900 (602 – 1297) | 846 (609 – 1364) | 0.8c |
Baseline CD4:CD8 ratioa | |||
Median (IQR) | 0.3 (0.2 – 0.5) | 0.2 (0.1 – 0.3) | 0.3c |
Baseline viral loada | |||
Median (IQR), log10 copies per ml | 4.6 (3.6 – 5.2) | 4.9 (3.7 – 5.1) | 0.06c |
cART combination antiretroviral therapy, TB tuberculosis, IQR interquartile range, MSM men who have sex with men, IDU injecting drug users
aBaseline was defined as the measurements taken at the date of cART initiation
bObtained using a χ2 test for difference in proportion
cObtained using a non-parametric K-sample test on the equality of medians