Table 2.
Change in biomarkers since cART initiation among HIV-infected patients in the ClinSurv HIV cohort, 1999-2013
| Biomarkers | Estimated change over time on cART (per year) | P value |
|---|---|---|
| CD4+ count | 43.9 cells per μl (95% CI 43.1 to 44.6) | <0.001 |
| CD8+ count | −27.9 cells per μl (95% CI −28.6 to −27.2) | <0.001 |
| CD4:CD8 ratio | 0.06 (95% 0.06 to 0.07) | <0.001 |
| Viral load | −0.1 log10 copies per ml (95% CI −0.1 to −0.1) | <0.001 |
| Biomarkers | Estimated mean of difference in change of biomarkers between cART-treated patients developing TB vs. those who remained free of TB | P value |
| CD4+ count | −33 cells per μl (95% CI −44.6 to 21.2) | 0.001 |
| CD8+ count | −72 cells per μl (95% CI −84.6 to 1.7) | 0.1 |
| CD4:CD8 ratio | −0.01 (95% CI −0.03 to 0.01) | 0.2 |
| Viral load | 0.01 log10 copies per ml (−0.04 to 0 .06) | 0.7 |
cART combination antiretroviral therapy, TB tuberculosis, IQR interquartile range
Longitudinal mixed models adjusted for sex, geographical origin, HIV transmission routes, age, year of cART initiation and baseline value of biomarkers (CD4+ count, CD8+ count, and viral load) and including interaction term between time and TB