Lethal event enhancement distributions for (a, d) circular and (b, c, e, f) elliptical F-98. For elliptical cells, the major/minor axis ratio is 44/20.5 μm for F-98 cells. The circular nucleus was located along the major/minor axis and membrane distance between cell and nucleus was 50 nm. The GNPs, of diameter 15 nm, had a concentration in the extracellular media of 2% by weight. The percentage refers to the sub-regions per nucleus diameter. The area excluding the nucleus is masked as 1.