Lethal event enhancement distributions for (a, d) circular and (b, c, e, f) elliptical MDA-MB-231. For elliptical cells, the major/minor axis ratio is 15.5/11.5 μm for MDA-MB-231. The circular nucleus was located along the major/minor axis and the membrane distance between the cell and the nucleus was 50 nm. The GNPs, with diameter of 15 nm, had a concentration in the extracellular media of 2% by weight. The percentage refers to the sub-regions per nucleus diameter. The area excluding the nucleus is masked as 1.