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. Author manuscript; available in PMC: 2017 Jul 25.
Published in final edited form as: Atherosclerosis. 2015 Jan 31;239(2):304–310. doi: 10.1016/j.atherosclerosis.2015.01.032

Table 2. Associations of a genetic predisposition score of 45 coronary heart disease-associated loci with coronary heart disease, plaque presence and intima-media thickness of the bulb and common carotid artery after meta-analysis of results from the IMPROVE, MDC-CC, ULSAM and PIVUS studies.

Model 1 Model 2
OR/beta 95% CI p_uw p_w N I2 OR/beta 95% CI p_uw p_w N I2
Coronary heart disease 1.053 1.030 1.077 5.43x10-6 - 5,512 60 1.055 1.031 1.079 4.13x10-6 - 5,370 56
Plaque presence 1.030 1.018 1.043 6.63x10-7 4.51x10-8 7,636 63 1.028 1.016 1.041 7.35x10-6 1.35x10-6 7,503 56
IMT bulb 2.93x10-3 1.25x10-3 4.61x10-3 6.26x10-4 8.55x10-5 7,480 68 2.44x10-3 7.77x10-4 4.11x10-3 4.03x10-3 1.39x10-3 7,350 66
IMT CCA 7.66x10-4 -8.28x10-5 1.61x10-3 0.08 1.68x10-2 9,582 59 3.11x10-4 -5.27x10-4 1.15x10-3 0.47 0.21 9,445 52

Model 1 shows associations adjusted for sex and age; model 2 shows associations adjusted for sex, age and Framingham risk factors, i.e. LDL-cholesterol, natural log transformed HDL-cholesterol, systolic blood pressure, diabetes and current smoking; odds ratios (OR) are shown for the association of a genetic predisposition score of the 45 coronary heart disease-associated loci with coronary heart disease and plaque presence at the far wall of the bulb, also known as sinus; betas are shown for the association of a genetic predisposition score with intima-media thickness (IMT) at the far wall of the bulb and common carotid artery (CCA); ORs, betas and their 95% confidence intervals show the effect size per risk allele across the 45 loci - the effect size for association with CHD as described earlier was not taken into account (i.e. an unweighted score); p_uw shows the p-value for the unweighted genetic predisposition score; p_w shows the p-value for a genetic predisposition score in which the effect size of each individual SNP for CHD risk is taken into account (Deloukas et al., 2013 [PMID 23202125]); I2 indicates the proportion of variation in effect size across studies that is due to true heterogeneity. Associations were considered significant if p<0.05 for coronary heart disease, and p<0.017 for carotid atherosclerosis traits, i.e. an α of 0.05 adjusted for three traits.