Table 1.

Lipid-Related Genetic Variants Associated with Age-Related Macular Degeneration Risk at a Bonferroni-Corrected Level of Significance

Single Nucleotide Polymorphism	Nearest Gene	Association of Variant with… (Beta Coefficient and P Value)
		LDL-c	HDL-c	Triglycerides	AMD Risk
rs1883025 (C)	ABCA1	0.030, P = 1×10−11	0.070, P = 6×10−66	0.022, P = 3×10−8	0.104, P = 2×10−7
rs653178 (C)	ATXN2	−0.023, P = 2×10−9	−0.026, P = 1×10−13	0.010, P = 0.004	0.064, P = 0.0002
rs1532085 (G)	LIPC	−0.003, P = 0.48	−0.107, P = 2×10−209	−0.031, P = 5×10−20	0.123, P = 3×10−12
rs261342 (C)	LIPC	0.003, P = 0.69	−0.107, P =6 ×10−71	−0.045, P = 4×10−14	0.117, P = 1×10−9
rs9989419 (G)	CETP	−0.028, P = 8×10−13	0.147, P = 8×10−373	−0.024, P = 3×10−12	0.109, P = 3×10−10
rs5880 (G)	CETP	−0.047, P = 9×10−7	0.307, P = 4×10−257	−0.048, P = 3×10−8	0.144, P = 6×10−5
rs6859 (G)	PVRL2	−0.084, P = 1×10−101	0.018, P =1 ×10−6	−0.014, P = 6×10−5	0.077, P = 8×10−6
rs103294 (T)	LILRB2/LILRA5	0.007, P = 0.12	0.052, P = 4×10−33	−0.002, P = 0.61	0.087, P = 6×10−5
rs4465830 (A)	ZNF335	−0.009, P = 0.06	0.060, P = 4×10−42	−0.053, P = 5×10−36	0.087, P = 4×10−5

Single nucleotide polymorphisms (effect alleles) are those associated with age-related macular degeneration (AMD) risk at a Bonferroni-corrected level of significance (P < 0.05/182 = 0.0003). Beta-coefficients for lipid fractions (low-density lipoprotein cholesterol [LDL-c], high-density lipoprotein cholesterol [HDL-c], and triglycerides) represent changes in the lipid fraction per additional copy of the effect allele in standard deviation units. Beta-coefficients for AMD represent log odds ratios (ORs) per additional copy of the effect allele. Boldface indicates association at a genome-wide level of significance (P < 5×10⁻⁸); italics indicate association at a Bonferroni-corrected level of significance. All variants are oriented to the AMD risk-increasing allele.