Table 2.

Genetic Proxies for Lipid Therapy and Their Associations with Disease Outcomes

Single Nucleotide Polymorphism	Gene Region	Association of Variant with… (Beta Coefficient and P Value)
		LDL-c	HDL-c	Triglycerides	AMD Risk	CAD Risk	ALZ Risk
rs12067569 (G)	PCSK9∗	−0.089	0.007	0.005	0.020	−0.048	−0.048
		P = 9×10−11	P = 0.33	P = 0.52	P = 0.61	P = 0.04	P = 0.25
rs7703051 (C)	HMGCR	−0.073	−0.002	−0.006	0.044	−0.030	−0.015
		P = 5×10−85	P = 0.56	P = 0.09	P = 0.010	P = 0.002	P = 0.37
rs2297374 (T)	LPA	−0.032	0.006	−0.009	0.026	−0.038	−0.014
		P = 6×10−18	P = 0.11	P = 0.008	P = 0.14	P = 8×10−5	P = 0.40
rs1564348 (T)	LPA	−0.048	0.008	−0.016	0.026	−0.030	−0.007
		P = 3×10−22	P = 0.10	P = 0.0003	P = 0.28	P = 0.022	P = 0.74
rs2073547 (A)	NPC1L1	−0.048	0.005	−0.015	0.021	−0.021	0.025
		P = 5×10−23	P = 0.28	P = 0.0009	P = 0.32	P = 0.08	P = 0.24
rs217386 (A)	NPC1L1	−0.036	0.001	−0.010	0.031	−0.022	0.005
		P = 8×10−22	P = 0.71	P = 0.003	P = 0.08	P = 0.029	P = 0.77
rs10790162 (A)	APOC3	0.076	−0.095	0.230	0.042	0.043	0.046
		P = 3×10−26	P = 3×10−46	P = 1×10−276	P = 0.16	P = 0.004	P = 0.13
rs603446 (C)	APOC3	0.009	−0.002	0.050	0.006	0.015	0.032
		P = 0.013	P = 0.60	P = 2×10−50	P = 0.73	P = 0.12	P = 0.05
rs9989419 (G)	CETP	−0.028	0.147	−0.024	0.109	−0.009	0.008
		P = 8×10−13	P = 8×10−373	P = 3×10−12	P = 3×10−10	P = 0.36	P = 0.63
rs5880 (G)	CETP	−0.047	0.307	−0.048	0.144	−0.007	0.027
		P = 9×10−7	P = 4×10−257	P = 3×10−8	P = 6×10−5	P = 0.75	P = 0.52
rs6859 (G)	APOE	−0.084	0.018	−0.014	0.077	−0.026	−0.334
		P = 1×10−101	P = 1×10−6	P = 6×10−5	P = 8×10−6	P = 0.010	P = 9×10−97
rs7254892 (A)	APOE	−0.485	0.053	0.124	0.063	−0.078	−0.250
		P = 8×10−365	P = 3×10−6	P = 4×10−31	P = 0.19	P = 0.009	P = 1×10−5

Single nucleotide polymorphisms (effect alleles) are the lead variants in each gene region taken from the Global Lipids Genetics Consortium. Associations with lipid fractions (low-density lipoprotein cholesterol [LDL-c], high-density lipoprotein cholesterol [HDL-c]. and triglycerides) are in standard deviation units. Associations with disease outcomes (age-related macular degeneration [AMD], coronary artery disease [CAD], Alzheimer's disease [ALZ]) are log odds ratios from logistic regression analyses. Boldface indicates association at a genome-wide level of significance (P < 5×10⁻⁸); italics indicate association at a Bonferroni-corrected level of significance (P < 0.05/182 = 0.0003). All variants are orientated to the AMD risk-increasing allele.

^∗The original lead variant reported for the PCSK9 gene region (rs188026950) was not available in the AMD, CAD, or ALZ consortium data.