Table 4.
Results from Multivariable Mendelian Randomization on All Lipid Fractions in Single Model
| Lipid Fraction | Method | AMD | CAD | ALZ∗ |
|---|---|---|---|---|
| LDL-c | Multivariable MR | 0.96 (0.83–1.11) | 1.48 (1.36–1.61) | 1.02 (0.93–1.14) |
| P = 0.55 | P = 2×10−21 | P = 0.58 | ||
| HDL-c | Multivariable MR | 1.18 (1.01–1.38) | 0.93 (0.85–1.02) | 0.94 (0.84–1.05) |
| P = 0.03 | P = 0.13 | P = 0.25 | ||
| Triglycerides | Multivariable MR | 1.04 (0.77–1.12) | 1.16 (1.04–1.29) | 0.93 (0.82–1.07) |
| P = 0.44 | P = 0.009 | P = 0.31 |
ALZ = Alzheimer's disease; AMD = age-related macular degeneration; CAD = coronary artery disease; HDL-c = high-density lipoprotein cholesterol; LDL-c = low-density lipoprotein cholesterol; MR = Mendelian randomization.
Estimates are odds ratios (95% confidence intervals) for the effect of a 1 standard deviation increase in the lipid fraction. All genetic variants that are associated with at least 1 lipid fraction at a genome-wide level of significance (P < 5×10−8) are included in the analyses.
∗
Variants from the APOE gene region were omitted from analyses for Alzheimer's disease because they dominated the results.