Figure 4.

Self-organizing maps of the seven plasma metabolite classes (amino acids, endocannabinoids, fatty acids, glucose, hydroxy acids, organic acids, and primary carbon metabolites) measured for a early- and b late-fasted northern elephant seal pups following an exogenous insulin infusion. Metabolite trajectories are shown within the map nodes. The seven metabolite classes were grouped by area under the curve (AUC) using hierarchical clustering into four clusters in both c early and d late fast. The circular diagram shows how each metabolite class transitions into a new cluster from early fast (left hemisphere) to late fast (right hemisphere). The metabolite classes are arranged according to their response to insulin with increasing values for AUC from top to bottom