Table 1.
Mean area under the curves (AUC; ± SD) for significantly different (p < 0.05) metabolites from the plasma metabolite classes (endocannabinoids, fatty acids, amino acids, carbohydrates, ketone bodies, and organic acids) measured for early- and late-fasted northern elephant seal pups. The metabolite’s pathway and metabolite class are identified.
| Metabolite | Pathway | Metabolite class | Early | Late |
|---|---|---|---|---|
| Anandamide (AEA) | Endocannabinoid metabolism | Endocannabinoid | 27 ± 71 | −73 ± 27 |
| Oleoylethanolamide (OEA) | Endocannabinoid metabolism | Endocannabinoid | 269 ± 690 | −627 ± 490 |
| Myristic acid (C14:0) | Lipid metabolism | Fatty acid | 36600 ± 7.2e+05 | −2.4e+06 ± 1.7e+06 |
| Palmitic Acid (C16:0) | Lipid metabolism | Fatty acid | −3320 ± 6000 | −13700 ± 6400* |
| Isoheptadecanoic acid (C17:0) | Lipid metabolism | Fatty acid | −7910 ± 110000 | −137000 ± 47000 |
| Vaccenic Acid (C18:1n7) | Lipid metabolism | Fatty acid | −304 ± 1700 | −3380 ± 2400 |
| Elaidic acid (C18:1n9) | Lipid metabolism | Fatty acid | 4.2e+06 ± 1.6e+06 | −5.5e+06 ± 2.3e+06* |
| Oleic Acid (C18:1n9) | Lipid metabolism | Fatty acid | −3350 ± 11000 | −29300 ± 12000* |
| Linoleic Acid (C18:2n6) | Lipid metabolism | Fatty acid | −93 ± 540 | −1290 ± 830 |
| Alanine | Amino acid metabolism | Amino acid | −9.7e+06 ± 4.6e+06 | 5e+06 ± 6.5e+06 |
| Beta-alanine | Pantothenate and pyrimidine metabolism | Amino acid | −5740 ± 16000 | 21400 ± 8100 |
| Isoleucine | Amino acid metabolism | Amino acid | −1670000 ± 1e+06 | −3.6e+06 ± 1.2e+06 |
| N-acetylglutamate | Amino acid metabolism | Amino acid | −9120 ± 9000 | 9730 ± 13000 |
| Erythritol | Carbohydrate metabolism | Carbohydrate | 607 ± 75000 | 125000 ± 75000 |
| Hexuronic acid | Carbohydrate metabolism, pentose phosphate pathway, ascorbic acid metabolism | Carbohydrate | 18600 ± 31000 | 81800 ± 43000 |
| Isothreonic acid | Carbohydrate metabolism, ascorbic acid metabolism | Carbohydrate | 28400 ± 35000 | 103000 ± 38000 |
| D-arabitol | Carbohydrate metabolism, pentose phosphate pathway | Carbohydrate | 9500 ± 28000 | 52000 ± 15000 |
| Maltose | Carbohydrate metabolism | Carbohydrate | −78600 ± 51000 | 34300 ± 87000 |
| D-Xylose | Carbohydrate metabolism | Carbohydrate | 21100 ± 90000 | 179000 ± 78000* |
| 3-Hydroxybutyric acid | Ketogenesis, Ketolysis | Ketone body | 3.3e+06 ± 5.7e+06 | −1.4e+07 ± 7.2e+06 |
| Hydroxybutyric acid | Ketogenesis, Ketolysis | Ketone body | 82600 ± 35000 | 194000 ± 85000* |
| Indole-3-lactate | Amino acid metabolism | Organic acid | −2110 ± 31000 | 58200 ± 24000* |
| Pyruvic acid | Glycolysis, gluconeogenesis, pyruvate metabolism | Organic acid | 6.5e+05 ± 4.9e+05 | 2.1e+06 ± 7.6e+05* |
Symbol
*
FDR adjusted p-value <0.05